What is BRAF?

BRAF is the name of both a gene and a protein. The BRAF protein helps control cell growth. When there is a mutation in the BRAF gene, it creates an abnormal protein that sends signals that lead to uncontrolled cell growth and cancer.  The BRAF protein works with another protein called MEK to regulate the growth of cells.

 

BRAF mutations have been reported in about 3% of non-small cell lung cancers (NSCLC). They are most common in adenocarcinoma non-small cell lung cancer. BRAF V600E mutations specifically occur in about 2% of non-small cell lung cancer patients.

​

There are different mutations within BRAF, and not all targeted therapy's work the same within the BRAF mutations. This is why getting a biomarker test is so important to your specific treatment options.